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E. A. Hoffman, R. Jiang, H. Baumhauer, M. A. Brooks, J. J. Carr, R. Detrano, J. M. Reinhardt, J. Rodriguez, K. Stukovsky, N. Wong, and R. G. Barr. Reproducibility and validity of lung density measures from cardiac CT Scans -- The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Acad. Radiol., vol. 16, no. 6, pp. 689-699, 2009.

Abstract: RATIONALE AND OBJECTIVES: Cardiac computed tomographic (CT) scans for the assessment of coronary calcium scores include approximately 70% of the lung volume and may be useful for the quantitative assessment of emphysema. The reproducibility of lung density measures from cardiac computed tomography and their validity compared to lung density measures from full-lung scans is unknown. MATERIALS AND METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) performed paired cardiac CT scans for 6814 participants at baseline and at follow-up. The MESA-Lung Study assessed lung density measures in the lung fields of these cardiac scans, counting voxels below -910 HU as moderate-to-severe emphysema-like lung regions. We evaluated: 1) the reproducibility of lung density measures among 120 randomly selected participants; 2) the comparability of measures acquired on electron beam CT (EBCT) and multidetector CT (MDCT) scanners among 10 participants; and 3) the validity of these measures compared to full-lung scans among 42 participants. Limits of agreement were determined using Bland-Altman approaches. RESULTS: Percent emphysema measures from paired cardiac scans were highly correlated (r = 0.92-0.95) with mean difference of -0.05% (95% limits of agreement: -8.3, 8.4%). Measures from EBCT and MDCT scanners were comparable (mean difference -0.9%; 95% limits of agreement: -5.1, 3.3%). Percent emphysema measures from MDCT cardiac and MDCT full-lung scans were highly correlated (r = 0.93) and demonstrated reasonable agreement (mean difference 2.2%; 95% limits of agreement: -9.2, 13.8%). CONCLUSIONS: Although full-lung imaging is preferred for the quantification of emphysema, the lung imaging from paired cardiac computed tomography provided a reproducible and valid quantitative assessment of emphysema in a population-based sample.

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Keywords: lung

Other publications by: E. A. Hoffman, R. Jiang, H. Baumhauer, M. A. Brooks, J. J. Carr, R. Detrano, J. M. Reinhardt, J. Rodriguez, K. Stukovsky, N. Wong, R. G. Barr

Related journal papers:

J. M. Reinhardt and E. A. Hoffman. Quantitative Pulmonary Imaging: Spatial and Temporal Considerations in HRCT. Acad. Radiol., vol. 5, no. 8, pp. 539-546, 1998. (details)
S. Hu, E. A. Hoffman, and J. M. Reinhardt. Automatic lung segmentation for accurate quantitation of volumetric X-ray CT images. IEEE Trans. Medical Imaging, vol. 20, no. 6, pp. 490-498, 2001. (details)
B. Li, G. E. Christensen, G. McLennan, E. A. Hoffman, and J. M. Reinhardt. Establishing a normative atlas of the human lung: Inter-subject warping and registration of volumetric CT. Acad. Radiol., vol. 10, no. 3, pp. 255-265, 2003. (details)
E. A. Hoffman, J. M. Reinhardt, M. Sonka, B. A. Simon, J. Guo, O. Saba, D. Chon, S. Samrah, H. Shikata, J. Tschirren, K. Palagyi, K. C. Beck, and G. McLennan. Characterization of the Interstitial Lung Diseases via Density-Based and Texture-Based Analysis of Computed Tomography Images of Lung Structure and Function. Acad. Radiol., vol. 10, no. 10, pp. 1104-1118, 2003. (details)
E. A. Hoffman, A. V. Clough, G. E. Christensen, C.-L. Lin, G. McLennan, J. M. Reinhardt, B. A. Simon, M. Sonka, M. Tawhai, E. van Beek, and G. Wang. The comprehensive imaging-based analysis of the lung: A forum for team science. Acad. Radiol., vol. 11, no. 12, pp. 1370-1380, 2004. (details)

Related conference papers:

E. A. Hoffman, J. M. Reinhardt, J. K. Tajik, and B. Q. Tran. Physiologic assessment of the lung via X-ray CT. In E. A. Hoffman, ed., Proc. SPIE Conf. Medical Imaging, vol. 3033, Newport Beach, CA, 1997. (details)
L. Zhang and J. M. Reinhardt. 3D pulmonary CT image registration with a standard lung atlas. In C.-T. Chen and A. V. Clough, eds., Proc. SPIE Conf. Medical Imaging, vol. 3978, pp. 67-77, San Diego, CA, 2000. (details)
B. Li and J. M. Reinhardt. Automatic generation of 3-D shape models and their application to tomographic image segmentation. In M. Sonka and K. M. Hansen, eds., Proc. SPIE Conf. Medical Imaging, vol. 4322, pp. 311-322, San Diego, CA, 2001. (details)
F. Li, C.-W. Chen, E. A. Hoffman, and J. M. Reinhardt. Evaluation and application of 3D lung warping and registration model using HRCT images. In C.-T. Chen and A. V. Clough, eds., Proc. SPIE Conf. Medical Imaging, vol. 4321, pp. 234-243, San Diego, CA, 2001. (details)
B. Li, G. E. Christensen, J. Dill, E. A. Hoffman, and J. M. Reinhardt. 3-D inter-subject warping and registration of pulmonary CT images for a human lung model. In A. V. Clough and C.-T. Chen, eds., Proc. SPIE Conf. Medical Imaging, vol. 4683, pp. 324-335, San Diego, CA, 2002. (details)

Related theses:

K. Ding. Registration-based regional lung mechanical analysis. MS thesis, The University of Iowa, Iowa City, IA, 2008. (details)
B. Li. The construction of a normative human lung atlas by inter-subject registration and warping of CT images. PhD thesis, The University of Iowa, Iowa City, IA, 2004. (details)
Y. Pan. Estimation of regional lung expansion via 3D image registration. MS thesis, The University of Iowa, Iowa City, IA, 2005. (details)