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O. Saba, E. A. Hoffman, and J. M. Reinhardt. Computed tomographic-based estimation of airway size with correction for scanned plane tilt angle. In C.-T. Chen and A. V. Clough, eds., Proc. SPIE Conf. Medical Imaging, vol. 3978, pp. 58-66, San Diego, CA, 2000.

Abstract: A new technique for airway measurement that simultaneously estimates airway tilt angle, caliber, and wall thickness is presented. An idealized (circular cross-section) airway model is parameterized by airway caliber, wall thickness, and tilt angle. Using a 2D CT slice and the full-width-half-max principle we form an estimate of the inner and outer airway wall locations. We then fit ellipses to the inner and outer airway walls using a direct least squares fit and use the major and minor axes of the ellipses to estimate the tilt angle. The airway model is then initialized with tilt angle and size estimates and convolved with the 3D scanner PSF to generate a predicted image. We compare predicted versus actual images to determine the goodness-of-fit. The initial airway parameters are refined using a multi-dimensional, unconstrained, non-linear minimization routine (Nelder-Mead). When optimization converges, airway model parameters estimate the airway inner and outer radii, and tilt angle. Results using a plexiglass phantom show that tilt angle could be estimated to within +/-5%, the inner radius to within about one half of a pixel, and the outer radius to within one pixel.

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Keywords: airways measurement

Other publications by: O. Saba, E. A. Hoffman, J. M. Reinhardt

Related journal papers:

J. M. Reinhardt, N. D. D'Souza, and E. A. Hoffman. Accurate Measurement of Intra-Thoracic Airways. IEEE Trans. Medical Imaging, vol. 16, no. 6, pp. 820-827, 1997. (details)
O. Saba, E. A. Hoffman, and J. M. Reinhardt. Maximizing Quantitative Accuracy of Lung Airway Lumen and Wall Measures Obtained from X-ray CT Imaging. J. Applied Physiology, vol. 95, pp. 1063-1095, 2003. (details)
T. E. Robinson, F. R. Long, P. Raman, P. Saha, M. J. Edmond, J. M. Reinhardt, R. Raman, and A. S. Brody. An airway phantom to standardize CT acquisition in multi-center clinical trials. Acad. Radiol., vol. 16, no. 9, pp. 1134-1141, 2009. (details)
C. P. Rooney, M. Suter, G. McLennan, M. Donnelley, J. M. Reinhardt, A. Delsing, E. A. Hoffman, and J. Zabner. Laser Fluorescence Bronchoscopy for Detection of Fluorescent Reporter Genes in Airway Epithelia. Gene Therapy, vol. 9, no. 23, pp. 1639-1644, 2002. (details)
D. Aykac, E. A. Hoffman, G. McLennan, and J. M. Reinhardt. Segmentation and analysis of the human airway tree from three-dimensional X-Ray CT images. IEEE Trans. Medical Imaging, vol. 22, no. 8, pp. 940-950, 2003. (details)

Related conference papers:

N. D. D'Souza, J. M. Reinhardt, and E. A. Hoffman. ASAP: Interactive Quantification of 2D Airway Geometry. In E. A. Hoffman, ed., Proc. SPIE Conf. Medical Imaging, vol. 2709, pp. 180-196, Newport Beach, CA, 1996. (details)
R. A. Chiplunkar, J. M. Reinhardt, and E. A. Hoffman. Segmentation and Quantification of the Primary Human Airway Tree from 3-D X-ray CT. In E. A. Hoffman, ed., Proc. SPIE Conf. Medical Imaging, vol. 3033, pp. 403-414, Newport Beach, CA, 1997. (details)
J. M. Reinhardt, S. A. Raab, N. D. D'Souza, and E. A. Hoffman. Intra-thoracic airway measurement: Ex vivo validation. In E. A. Hoffman, ed., Proc. SPIE Conf. Medical Imaging, vol. 3033, pp. 69-80, Newport Beach, CA, 1997. (details)
J. M. Reinhardt, W. Park, E. A. Hoffman, and M. Sonka. Intrathoracic airway wall detection using graph search with CT scanner PSF information. In E. A. Hoffman, ed., Proc. SPIE Conf. Medical Imaging, vol. 3033, pp. 93-101, Newport Beach, CA, 1997. (details)
J. Thiesse, J. M. Reinhardt, J. de Ryk, J. Leinen, W. Recheis, E. A. Hoffman, and G. McLennan. Three-dimensional visual truth of the normal airway tree for use as a quantitative comparison to micro-CT reconstructions. In A. Amini and A. Manduca, eds., Proc. SPIE Conf. Medical Imaging, vol. 5746, pp. 369-383, San Diego, CA, 2005. (details)

Related theses:

O. Saba. Accurate estimation of airway geometry with tilt angle estimation from 2D HRCT slices. MS thesis, The University of Iowa, Iowa City, IA, 2000. (details)
D. Aykac. Segmentation and analysis of the human airway tree from 3D X-ray CT images. MS thesis, The University of Iowa, Iowa City, IA, 2000. (details)
D. Gopalakrishnan. Color analysis of the human airway wall. MS thesis, The University of Iowa, Iowa City, IA, 2003. (details)
P. Kellen. Computer automated image analysis of fluoroscopic swallowing studies. MS thesis, The University of Iowa, Iowa City, IA, 2008. (details)
S. V. Bodas. Improved association graph matching of intra-patient airway trees. MS thesis, The University of Iowa, Iowa City, IA, 2008. (details)