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C. P. Rooney, M. Suter, G. McLennan, M. Donnelley, J. M. Reinhardt, A. Delsing, E. A. Hoffman, and J. Zabner. Laser Fluorescence Bronchoscopy for Detection of Fluorescent Reporter Genes in Airway Epithelia. Gene Therapy, vol. 9, no. 23, pp. 1639-1644, 2002.

Abstract: Current methods for detecting successful gene transfer to airway epithelia involve obtaining a sample of the target tissue. This may affect the longevity of expression of the transgene under evaluation. We describe a laser fluorescence bronchoscopic system that can detect the expression of the fluorescent protein, green fluorescence protein (GFP), in the airway of monkeys that have been transfected with adenovirus, without the need for obtaining tissue. This technique will have applications in pre-clinical and clinical studies of gene transfer to airway epithelia and other surface epithelia accessible by endoscopy.

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Keywords: airways bronchoscopy

Other publications by: C. P. Rooney, M. Suter, G. McLennan, M. Donnelley, J. M. Reinhardt, A. Delsing, E. A. Hoffman, J. Zabner

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M. Suter, J. Tschirren, J. M. Reinhardt, M. Sonka, E. A. Hoffman, W. E. Higgins, and G. McLennan. Evaluation of the human airway with multi-detector X-ray computed tomography and optical imaging. Physiological Measurement, vol. 25, no. 4, pp. 837-847, 2004. (details)
M. Suter, J. M. Reinhardt, P. Montague, P. Taft, J. Lee, J. Zabner, and G. McLennan. Bronchoscopic imaging of the pulmonary mucosal vasculature responses to inflammatory mediators. J. Biomed. Optics, vol. 10, no. 3, pg. 34013, 2005. (details)
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Related conference papers:

R. D. Swift, W. E. Higgins, E. A. Hoffman, G. McLennan, and J. M. Reinhardt. Automatic axis generation for 3D virtual-bronchoscopic image assessment. In E. A. Hoffman, ed., Proc. SPIE Conf. Medical Imaging, vol. 3337, pp. 73-84, San Diego, CA, 1998. (details)
A. Kiraly, W. E. Higgins, E. A. Hoffman, G. McLennan, and J. M. Reinhardt. 3D human airway segmentation for virtual bronchoscopy. In A. V. Clough and C.-T. Chen, eds., Proc. SPIE Conf. Medical Imaging, vol. 4683, pp. 16-29, San Diego, CA, 2002. (details)
D. Gopalakrishnan, G. McLennan, M. Donnelley, A. Delsing, M. Suter, D. Flaherty, J. Zabner, E. A. Hoffman, and J. M. Reinhardt. Color bronchoscopic analysis of the human airway tree. In A. V. Clough and C.-T. Chen, eds., Proc. SPIE Conf. Medical Imaging, vol. 4683, pp. 341-351, San Diego, CA, 2002. (details)
M. Suter, J. M. Reinhardt, M. Sonka, W. E. Higgins, E. A. Hoffman, and G. McLennan. Three-dimensional true color topographical analysis of the pulmonary airways. In A. Amini and A. Manduca, eds., Proc. SPIE Conf. Medical Imaging, vol. 5369, pp. 189-198, San Diego, CA, 2004. (details)
A. Kiraly, J. M. Reinhardt, E. A. Hoffman, G. McLennan, and W. E. Higgins. Virtual bronchoscopy for quantitative airway analysis. In A. Amini and A. Manduca, eds., Proc. SPIE Conf. Medical Imaging, vol. 5746, pp. 369-383, San Diego, CA, 2005. (details)

Related theses:

D. Gopalakrishnan. Color analysis of the human airway wall. MS thesis, The University of Iowa, Iowa City, IA, 2003. (details)
D. Aykac. Segmentation and analysis of the human airway tree from 3D X-ray CT images. MS thesis, The University of Iowa, Iowa City, IA, 2000. (details)
O. Saba. Accurate estimation of airway geometry with tilt angle estimation from 2D HRCT slices. MS thesis, The University of Iowa, Iowa City, IA, 2000. (details)
S. V. Bodas. Improved association graph matching of intra-patient airway trees. MS thesis, The University of Iowa, Iowa City, IA, 2008. (details)