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J. M. Reinhardt, G. E. Christensen, E. A. Hoffman, K. Ding, and K. Cao. Registration-derived estimates of local lung expansion as surrogates for regional ventilation. In N. Karssemeijer and B. Lelieveldt , eds., Information Processing in Medical Imaging, vol. 4584 of Lecture Notes in Computer Science, pp. 763-774, Kerkrade, The Netherlands, 2007.

Abstract: The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian of the registration displacement field. We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, $r^2=0.89$ during gas wash-in) in one animal.

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Keywords: biomechanics lung registration ventilation

Other publications by: J. M. Reinhardt, G. E. Christensen, E. A. Hoffman, K. Ding, K. Cao

Related journal papers:

J. M. Reinhardt, K. Ding, K. Cao, G. E. Christensen, E. A. Hoffman, and S. V. Bodas. Registration-based estimates of local lung tissue expansion compared to xenon-CT measures of specific ventilation. Medical Image Analysis, vol. 12, no. 6, pp. 752-763, 2008. (details)
B. Li, G. E. Christensen, G. McLennan, E. A. Hoffman, and J. M. Reinhardt. Establishing a normative atlas of the human lung: Inter-subject warping and registration of volumetric CT. Acad. Radiol., vol. 10, no. 3, pp. 255-265, 2003. (details)
B. A. Simon, G. E. Christensen, D. A. Low, and J. M. Reinhardt. Computed Tomography Studies of Lung Mechanics. Proc Am Thorac Soc, vol. 2, no. 6, pp. 517-521, 2005. (details)
M. K. Fuld, R. B. Easley, O. Saba, D. Chon, J. M. Reinhardt, E. A. Hoffman, and B. A. Simon. CT measured regional specific volume change reflects regional specific ventilation in supine sheep. J. Applied Physiology, vol. 104, no. 4, pp. 1177-1184, 2008. (details)
B. Li, G. E. Christensen, G. McLennan, E. A. Hoffman, and J. M. Reinhardt. Pulmonary CT image registration and warping for tracking tissue deformation during the respiratory cycle through 3-D Consistent Image Registration. Medical Physics, vol. 35, no. 12, pp. 5575-5583, 2008. (details)

Related conference papers:

S. Krishnan, K. C. Beck, J. M. Reinhardt, K. A. Carlson, B. A. Simon, R. K. Albert, and E. A. Hoffman. Regional lung ventilation from volumetric CT scans using image warping functions. In 2004 International Symposium on Biomedical Imaging, pp. 792-795, 2004. (details)
Y. Pan, D. Kumar, E. A. Hoffman, G. E. Christensen, G. McLennan, J. H. Song, A. Ross, B. A. Simon, and J. M. Reinhardt. Regional lung expansion via 3D image registration. In A. Amini and A. Manduca, eds., Proc. SPIE Conf. Medical Imaging, vol. 5746, pp. 453-464, San Diego, CA, 2005. (details)
K. Ding, K. Cao, G. E. Christensen, E. A. Hoffman, and J. M. Reinhardt. Registration-based regional lung mechanical analysis: Retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition. In X. P. Hu and A. V. Clough, eds., Proc. SPIE Conf. Medical Imaging, vol. 7262, Lake Buena Vista, FL, 2009. (details)
K. Ding, K. Cao, G. E. Christensen, M. L. Raghavan, E. A. Hoffman, and J. M. Reinhardt. Registration-based lung tissue mechanics assessment during tidal breathing. In M. Brown, M. de Bruijne, B. van Ginneken, A. Kiraly, J.-M. Kuhnigk, C. Lorenz, K. Mori, and J. M. Reinhardt, eds., First International Workshop on Pulmonary Image Analysis, pp. 63-72, New York, 2008. (details)
K. Ding, Y. Yin, K. Cao, G. E. Christensen, C.-L. Lin, E. A. Hoffman, and J. M. Reinhardt. Evaluation of Lobar Biomechanics during Respiration using Image Registration. In G.-Z. Yang, D. J. Hawkes, D. Rueckert, A. Noble, and C. Taylor, eds., Medical Imaging Computing and Computer Assisted Intervention, vol. 5761 of Lecture Notes in Computer Science, pp. 739-746, London, UK, 2009. (details)

Related theses:

K. Ding. Registration-based regional lung mechanical analysis. MS thesis, The University of Iowa, Iowa City, IA, 2008. (details)
Y. Pan. Estimation of regional lung expansion via 3D image registration. MS thesis, The University of Iowa, Iowa City, IA, 2005. (details)
B. Li. The construction of a normative human lung atlas by inter-subject registration and warping of CT images. PhD thesis, The University of Iowa, Iowa City, IA, 2004. (details)
S. Lee. A study of ophthalmologic imaging distortion for retinal image registration and validation. PhD thesis, The University of Iowa, Iowa City, IA, 2008. (details)
S. V. Bodas. Improved association graph matching of intra-patient airway trees. MS thesis, The University of Iowa, Iowa City, IA, 2008. (details)